CBE Seminar: Manipulating Phase Separation of Elastomeric (Poly)Peptides to Make Micro- and Nanostructured Biomaterials

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Abstract: Macromolecular structures that are capable of selectively and efficiently engaging cellular targets offer important approaches for mediating biological events and in the development of hybrid materials. We have employed a combination of biosynthetic tools, bioconjugation strategies and biomimetic assembly to produce thermoresponsive (poly)peptides derived from sequences of resilin, elastin and collagen. These materials can be designed to control localization of biomolecules with tunable microscale mechanics, and materials with select properties have demonstrated promise for healing vascular graft materials in vivo. In addition, these types of materials not only show controllable micro- and nanoscale morphologies, but also have promise for targeted drug delivery to damaged tissue in vivo.

Bio: Kristi Kiick is a professor and chair of the Department of Biomedical Engineering and the Blue and Gold Distinguished Professor of Materials Science and Engineering at the University of Delaware. She also holds affiliated faculty appointments in the Department of Biological Sciences at the University of Delaware and in the School of Pharmacy at the University of Nottingham, where Kiick has conducted research as a Leverhulme Visiting Professor and Fulbright Scholar. Her internationally recognized research focuses on the synthesis, characterization and application of protein, peptide and self-assembled materials for applications in tissue engineering, drug delivery and bioengineering, with specific research in cardiovascular, vocal fold and cancer therapies. A fellow of the National Academy of Inventors, American Association for the Advancement of Science, and American Chemical Society, she has published more than 150 articles, book chapters and patents, and has delivered over 200 invited and awarded lectures. Kiick’s honors include several awards (Camille and Henry Dreyfus Foundation New Faculty, Beckman Young Investigator, NSF CAREER, DuPont Young Professor and Delaware Biosciences Academic Research Award) as well as induction as a fellow of the American Institute for Medical and Biological Engineering and the American Chemical Society Division of Polymer Chemistry. She also serves on the advisory and editorial boards for multiple international journals and research organizations. Kiick received her bachelor's degree in chemistry from University of Delaware as a Eugene du Pont Memorial Distinguished Scholar, where she graduated summa cum laude, and a master's degree in chemistry as an NSF graduate fellow at the University of Georgia. She worked in industry (Kimberly Clark Corporation) as a research scientist prior to obtaining her master's degree and doctorate in polymer science and engineering at the University of Massachusetts Amherst. She completed her doctoral research at the California Institute of Technology as a recipient of a National Defense Science and Engineering Graduate (NDSEG) fellowship.

Host: Assistant Professor Herdeline Ardoña