Postdoctoral Scholars - Computational Protein Design with Ryan Hayes Research Group

$60,000 - $64,522 (based on experience level)

The computational research group of Ryan Hayes at UC Irvine has an immediate opening for a postdoctoral scholar. The postdoctoral scholar will develop molecular simulation methods with a rigorous basis in statistical mechanics for protein design calculations. The selected candidate will have access to campus computing facilities and extensive collaboration with the Mobley group. The position provides opportunities for theoretical development and protein design applications of methods that have longstanding utility in big pharma for computer-aided drug design of small molecules. Salary will be based on the candidate's skill set and previous experience.

Candidates should have a Ph.D. or foreign equivalent in chemical engineering, chemistry, physics, pharmacy or a related discipline with expertise in computation, molecular dynamics simulation and statistical mechanics. For a further description of current research projects, see or contact Ryan Hayes at:


  • Run and analyze simulations to develop the multisite lambda dynamics free-energy method for protein design
  • Scale multisite lambda dynamics simulations to larger combinatorial sequence spaces
  • Develop methods to focus sampling on promising sequences
  • Design new proteins in collaboration with experimental laboratories

Application Procedure: Applicants need to upload their curriculum vitae, cover letter describing research accomplishments and future career plans, and contact information for at least three references to our online RECRUIT system at

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

As a condition of employment, you will be required to comply with the University of California Policy on Vaccination Programs – With Updated Interim Amendments. All Covered Individuals under the policy must provide proof of receiving the COVID-19 Vaccine Primary Series or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, Religious Objection, and/or Deferral based on pregnancy or recent COVID-19 diagnosis and/or treatment) no later than the applicable deadline. All Covered Individuals must also provide proof of receiving the most recent CDC-recommended COVID-19 booster or properly decline such booster no later than the applicable deadline. New University of California employees should refer to Exhibit 2, Section II.C. of the SARS-CoV-2 (COVID-19) Vaccination Program Attachment for applicable deadlines. All Covered Individuals must also provide proof of being up-to-date on seasonal influenza vaccination or properly decline such vaccination no later than the applicable deadline. Please refer to the Seasonal Influenza Vaccination Program Attachment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.