CBE Seminar (Zoom): Stochastic Dynamics in the Cell - Computational Approaches to Bridge Models and Experiments
Department of Chemical and Biomolecular Engineering
Registration link for non-UCI people: https://forms.gle/9u31iubu8djqkQf37
Abstract: Cell biological data is increasingly available at single-cell, single-nucleotide and single-molecule resolution. Such experiments reveal often unexpected levels of heterogeneity at these scales. In the Read lab, we use stochastic chemical kinetics to model intracellular processes, interrogate this heterogeneity, and infer mechanistic insights from data.
I will present our recent work in computational methods development along several fronts. I will discuss methods for simulating rare events — these methods enable us to efficiently simulate multiscale temporal dynamics in biochemical networks and reaction-diffusion systems. I will also discuss techniques for merging data-driven and mechanistic modeling, in order to maximize information gain from data-rich measurements, including epigenomics and transcriptomics.
Bio: Elizabeth Read is assistant professor of chemical and biomolecular engineering at UC Irvine. She holds undergraduate degrees in chemistry and mathematics from the University of Colorado and a Ph.D. in chemistry from UC Berkeley. Read is a member of the UC Irvine Center for Complex Biological Systems and the NSF-Simons Center for Multiscale Cell Fate, and she was named a 2018 Scialog Fellow in the focus area chemical machinery of the cell.
Host: Professor Vasan Venugopalan