BME Lecture Series (Zoom): X. Edward Guo, Columbia University

Bone Bioengineering: Microstructure, Mechanics, Mechanobiology, and Beyond

Abstract: Bone bioengineering has both basic science and clinical significances in many medical fields, such as osteoporosis, osteoarthritis or intervertebral disc degenerations. I will highlight our development of a 3D imaging analysis and modeling technique for trabecular bone microstructure, its applications in basic science research of bone mechanics and clinical applications in osteoporosis and osteoarthritis. We will discuss bone microstructural phenotypes in different races and their implications in genetic and precision medicine, anthropology, evolution and mechanobiology of the skeletons. In parallel to these developments, we will also showcase how mechanobiology links to bone microstructure and mechanics.

Bio: X. Edward Guo directs the Bone Bioengineering Laboratory in the Department of Biomedical Engineering at Columbia University, focusing his research interests in micromechanics of bone tissue, computational biomechanics and mechanobiology of bone. He is an elected fellow of the American Institute for Medical and Biological Engineering, American Society of Mechanical Engineers, BMES and International Academy of Medical and Biological Engineering. He was one of the founders and served as co-editor-in-chief of Cellular and Molecular Bioengineering (CMBE), an international journal of BMES. He has served on many review panels for NIH, NSF and NASA. His research has been supported by the Whitaker Foundation, the NSF and the NIH. He has served as president of the International Chinese Musculoskeletal Research Society and Society for Physical Regulation in Biology and Medicine, and as a member of the Board of Directors of Orthopaedic Research Society and of the Board of Directors of AIMBE. Guo also founded the Special Interest Group in CMBE in the BMES and served as its founding chair.