Recent Breakthroughs in Centrifugal Based Microfluidics

ICS 174
ChEMS Seminar

Featuring Marc Madou, Ph.D.

Chancellor’s Professor, Mechanical and Aerospace Engineering, Biomedical Engineering, and Chemical Engineering and Materials Science

The Henry Samueli School of Engineering, UC Irvine

WCU Scholar, UNIST

Free and open to the public



Abstract:

We present some recent innovations that our team implemented on a centrifugal microfluidic platform. This includes:

  1. An advanced cell lysis system to efficiently lyse cells to extract nucleic acids and create a homogenized sample,
  2. Dielectrophoresis for cell sorting,
  3. Serial siphon valves for sequential controlled release of fluids in a temporally and spatially manner less influenced by dynamic changes of the hydrophobic/hydrophilic nature of the CD plastic,
  4. Pneumatic pumping achieved by compressing air by spinning a liquid sample, then slowing down the spin rate to lower the centripetal force and allow the trapped air to expand. The latter effect was used to pump liquid back to the center of the CD and also in pneumatic mixing.
  5. Finally, we used a native CD-ROM drive as a microscope for imaging microfluidics on the CD.